Deciphering the message in protein sequences: tolerance to amino acid substitutions

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Science  16 Mar 1990:
Vol. 247, Issue 4948, pp. 1306-1310
DOI: 10.1126/science.2315699


An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

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