Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor

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Science  20 Jul 1990:
Vol. 249, Issue 4966, pp. 296-298
DOI: 10.1126/science.2374928


Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma 1 (PLC-gamma 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-gamma 1 suggests that the membrane association of PLC-gamma 1 is a significant event in second messenger transduction.

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