Research Articles

How big is the universe of exons?

See allHide authors and affiliations

Science  07 Dec 1990:
Vol. 250, Issue 4986, pp. 1377-1382
DOI: 10.1126/science.2255907


If genes have been assembled from exon subunits, the frequency with which exons are reused leads to an estimate of the size of the underlying exon universe. An exon database was constructed from available protein sequences, and homologous exons were identified on the basis of amino acid identity; statistically significant matches were determined by Monte Carlo methods. It is estimated that only 1000 to 7000 exons were needed to construct all proteins.

Stay Connected to Science