The effect of anti-neoplastic drugs on murine acquired immunodeficiency syndrome

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Science  18 Jan 1991:
Vol. 251, Issue 4991, pp. 305-308
DOI: 10.1126/science.1987646


The murine acquired immunodeficiency syndrome (MAIDS) is associated with proliferation of target cells that have been infected by a defective retrovirus. To control the growth of this primary neoplasia, virus-inoculated mice were treated with anti-neoplastic drugs. Paradoxically, cyclophosphamide, which is also immunosuppressive, was very effective in preventing the appearance and progression of the disease, in restoring a normal T cell function, and in depleting the number of infected target cells. This result suggests that the proliferating infected target cells were responsible for the immunodeficiency.

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