Site-specific recombination between homologous chromosomes in Drosophila

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Science  17 May 1991:
Vol. 252, Issue 5008, pp. 958-961
DOI: 10.1126/science.2035025


The ability to mark a cell and its descendants genetically so that the resulting cell clone can be distinguished from neighboring cells facilitates studies in animal biology and development. A method of generating clones by inducing homologous mitotic recombination in Drosophila with a site-specific yeast recombinase is described. This method allows for frequent mosaicism after mitotic exchange is induced at predefined sites in the genome.

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