Alteration of four identified K+ currents in Drosophila muscle by mutations in eag

See allHide authors and affiliations

Science  14 Jun 1991:
Vol. 252, Issue 5012, pp. 1562-1564
DOI: 10.1126/science.2047864


Voltage-clamp analysis of Drosophila larval muscle revealed that ether a go-go (eag) mutations affected all identified potassium currents, including those specifically eliminated by mutations in the Shaker or slowpoke gene. Together with DNA sequence analysis, the results suggest that the eag locus encodes a subunit common to different potassium channels. Thus, combinatorial assembly of polypeptides from different genes may contribute to potassium channel diversity.

Stay Connected to Science