Toward a science of metabolic engineering

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Science  21 Jun 1991:
Vol. 252, Issue 5013, pp. 1668-1675
DOI: 10.1126/science.2047876


Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates. Recruitment of heterologous proteins enables extension of existing pathways to obtain new chemical products, alter posttranslational protein processing, and degrade recalcitrant wastes. Although some of the experimental and mathematical tools required for rational metabolic engineering are available, complex cellular responses to genetic perturbations can complicate predictive design.

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