Facilitation of the induction of long-term potentiation by GABAB receptors

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Science  21 Jun 1991:
Vol. 252, Issue 5013, pp. 1718-1720
DOI: 10.1126/science.1675489


Long-term potentiation (LTP), an in vitro model of learning, was induced in hippocampal slices by 5-hertz stimulation. During induction, gamma-aminobutyric acid A (GABAA) inhibition decreased, causing the N-methyl-D-aspartate receptor-mediated excitation to increase. 2-OH Saclofen, a GABAB receptor antagonist, prevented the reduction of inhibition, the increase of excitation, and the induction of LTP. Therefore, disinhibition caused by GABAB receptors is required for induction of LTP by 5-hertz stimulation. GABAB receptor modulation of synaptic plasticity occurs at frequencies in the range of the endogenous hippocampal theta rhythm, which has been shown to modulate LTP in vivo.