Requirement of microfilaments in sorting of actin messenger RNA

See allHide authors and affiliations

Science  13 Sep 1991:
Vol. 253, Issue 5025, pp. 1275-1277
DOI: 10.1126/science.1891715


Specific messenger RNAs (mRNAs) can be sequestered within distinct cellular locations, but little is known about how this is accomplished. The participation of the three major cellular filaments in the localization of actin mRNA was studied in chicken embryo fibroblasts. Movement of actin mRNA to the cell periphery and maintenance of that regionalization required intact microfilaments (composed of actin) but not microtubules or intermediate filaments. The results presented here suggest that actin-binding proteins may participate in mRNA sorting.

Stay Connected to Science