Control of granulocytes and macrophages: molecular, cellular, and clinical aspects

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Science  25 Oct 1991:
Vol. 254, Issue 5031, pp. 529-533
DOI: 10.1126/science.1948028


The production and functional activity of two important white blood cells, the granulocytes and macrophages, are regulated mainly by a group of glycoprotein colony-stimulating factors. The colony-stimulating factors have been mass-produced with recombinant technology and are now proving of value in preventing or suppressing infections in a variety of individuals with subnormal or defective formation of blood cells.