Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon

See allHide authors and affiliations

Science  03 Jan 1992:
Vol. 255, Issue 5040, pp. 79-82
DOI: 10.1126/science.1532456


The multichain T cell antigen receptor functions by interacting with and activating one or more nonreceptor tyrosine kinases. The cytoplasmic tail of the zeta chain can activate T cells independently of the rest of the receptor complex. The function of the remaining invariant CD3 chains remains unknown. A 22-amino acid region of the cytoplasmic tail of CD3 epsilon was also able to independently activate T cells. Stimulation of T cells by means of the cytoplasmic tails of either zeta or CD3 epsilon resulted in quantitatively distinct patterns of tyrosine phosphorylation, suggesting activation of different biochemical pathways.

Stay Connected to Science