The Son of sevenless gene product: a putative activator of Ras

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Science  31 Jan 1992:
Vol. 255, Issue 5044, pp. 603-606
DOI: 10.1126/science.1736363


The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.

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