Spatial control of the gap gene knirps in the Drosophila embryo by posterior morphogen system

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Science  21 Feb 1992:
Vol. 255, Issue 5047, pp. 986-989
DOI: 10.1126/science.1546296


The gap genes of Drosophila are the first zygotic genes to respond to the maternal positional signals and establish the body pattern along the anterior-posterior axis. The gap gene knirps, required for patterning in the posterior region of the embryo, can be activated throughout the wild-type embryo and is normally repressed from the anterior and posterior sides. These results provide direct molecular evidence that the posterior morphogen system interacts in a fundamentally different manner than do hunchback and bicoid, which are responsible for anterior pattern formation.

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