Mitochondrial genetics: a paradigm for aging and degenerative diseases?

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Science  01 May 1992:
Vol. 256, Issue 5057, pp. 628-632
DOI: 10.1126/science.1533953


Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging.

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