Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8-/- Mice

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Science  22 May 1992:
Vol. 256, Issue 5060, pp. 1210-1213
DOI: 10.1126/science.256.5060.1210


Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)susceptible PL/J H-2u through four backcross generations to investigate the role of CD8+ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8+ T lymphocytes may participate as both effectors and regulators in this animal model.