E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

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Science  16 Oct 1992:
Vol. 258, Issue 5081, pp. 424-429
DOI: 10.1126/science.1411535


The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.

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