Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

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Science  18 Dec 1992:
Vol. 258, Issue 5090, pp. 1955-1957
DOI: 10.1126/science.1470921


Programmed cell death is a physiological process that eliminates unwanted cells. The bcl-2 gene regulates programmed cell death in mammalian cells, but the way it functions is not known. Expression of the human bcl-2 gene in the nematode Caenorhabditis elegans reduced the number of programmed cell deaths, suggesting that the mechanism of programmed cell death controlled by bcl-2 in humans is the same as that in nematodes.

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