Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells

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Science  15 Jan 1993:
Vol. 259, Issue 5093, pp. 368-370
DOI: 10.1126/science.7678351


A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8+ T cells; CD4+ T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo.

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