Activity-dependent regulation of conductances in model neurons

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Science  26 Mar 1993:
Vol. 259, Issue 5103, pp. 1915-1917
DOI: 10.1126/science.8456317


Neurons maintain their electrical activity patterns despite channel turnover, cell growth, and variable extracellular conditions. A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity. Model neurons with activity-dependent maximal conductances modify their conductances to maintain a given behavior when perturbed. Moreover, neurons that are described by identical sets of equations can develop different properties in response to different patterns of presynaptic activity.

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