Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium

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Science  30 Apr 1993:
Vol. 260, Issue 5108, pp. 682-687
DOI: 10.1126/science.8097594


Cardiac hypertrophy in response to systolic pressure loading frequently results in contractile dysfunction of unknown cause. In the present study, pressure loading increased the microtubule component of the cardiac muscle cell cytoskeleton, which was responsible for the cellular contractile dysfunction observed. The linked microtubule and contractile abnormalities were persistent and thus may have significance for the deterioration of initially compensatory cardiac hypertrophy into congestive heart failure.

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