A detailed genetic map for the X chromosome of the malaria vector, Anopheles gambiae

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Science  30 Jul 1993:
Vol. 261, Issue 5121, pp. 605-608
DOI: 10.1126/science.8342025


Anopheles gambiae, the primary vector of human malaria in Africa, is responsible for approximately a million deaths per year, mostly of children. Despite its significance in disease transmission, this mosquito has not been studied extensively by genetic or molecular techniques. To facilitate studies on this vector, a genetic map has been developed that covers the X chromosome at an average resolution of 2 centimorgans. This map has been integrated with the chromosome banding pattern and used to localize a recessive, sex-linked mutation (white eye) to within 1 centimorgan of flanking markers.

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