Identification of a structural glycoprotein of an RNA virus as a ribonuclease

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Science  27 Aug 1993:
Vol. 261, Issue 5125, pp. 1169-1171
DOI: 10.1126/science.8356450


One of the three structural glycoproteins of classical swine fever virus (CSFV) is E0, a disulfide-bonded homodimer that induces virus-neutralizing antibodies and occurs in a virion-bound as well as a secreted form. E0 was shown to be similar to a family of fungal and plant ribonucleases. Purified E0 from CSFV-infected cells was a potent ribonuclease specific for uridine and inhibitable by zinc ions.