Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members

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Science  03 Dec 1993:
Vol. 262, Issue 5139, pp. 1557-1560
DOI: 10.1126/science.8248803


The E2F family of transcription factors functions in the control of the mammalian cell cycle. Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in vivo, a process that enhances DNA binding, transactivation, and the binding of the retinoblastoma gene product. These results suggest that heterodimerization regulates E2F function and contributes to cell cycle control.

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