Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands

See allHide authors and affiliations

Science  08 Apr 1994:
Vol. 264, Issue 5156, pp. 267-270
DOI: 10.1126/science.8146660


Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.

Stay Connected to Science