Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

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Science  13 May 1994:
Vol. 264, Issue 5161, pp. 965-968
DOI: 10.1126/science.8178155


A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.

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