20 May 1994
Vol 264, Issue 5162

About The Cover

On 13 September 1848, an explosion sent an iron rod rocketing through the head of Phineas Gage. He died in 1861 without being autopsied. Skull measurements were used to reconstruct a three-dimensional image of his brain and the trajectory of the rod. Pinpointing the lesion completes the historical record and restores Gage as a foundation for our contemporary understanding of the prefrontal cortices and their role in emotion, reason, and social behavior. See page 1102. [Digital image: Hanna Damasio, Department of Neurology and Image Analysis, University of Iowa College of Medicine]