Imaging with intermolecular multiple-quantum coherences in solution nuclear magnetic resonance

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Science  03 Feb 1995:
Vol. 267, Issue 5198, pp. 654-657
DOI: 10.1126/science.7839140


A magnetic resonance imaging technique based on intermolecular multiple-quantum coherences in solution (the correlated spectroscopy revamped by asymmetric z gradient echo detection or CRAZED experiment) is described here. Correlations between spins in different molecules were detected by magnetic-field gradient pulses. In order for a correlation to yield an observable signal, the separation between the two spins must be within a narrow band that depends on the area of the gradient pulses. The separation can be tuned from less than 10 micrometers to more than 1 millimeter, a convenient range for many applications.