Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons

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Science  07 Jul 1995:
Vol. 269, Issue 5220, pp. 98-101
DOI: 10.1126/science.7541558


Mouse retinal ganglion cell axons growing from the eye encounter embryonic neurons at the future site of the optic chiasm. After in vivo ablation of these chiasm neurons with a monoclonal antibody and complement, retinal axons did not cross the midline and stalled at approximately the entry site into the chiasm region. Thus, in the mouse, the presence of early-generated neurons that reside at the site of the future chiasm is required for formation of the optic chiasm by retinal ganglion cell axons.

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