Research NewsImmunology

How the Glucocorticoids Suppress Immunity

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Science  13 Oct 1995:
Vol. 270, Issue 5234, pp. 232-233
DOI: 10.1126/science.270.5234.232


Glucocorticoids have been used for decades as immune suppressants to treat allergic reactions, reduce inflammation, and prevent rejection of transplanted organs. But how they work has been something of a mystery. Now, two teams of researchers report in Science that they appear to work by stimulating cells to produce a protein, which in turn binds and inactivates a second protein normally involved in turning on genes that orchestrate an immune response.

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