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T Lymphocyte-Directed Gene Therapy for ADA SCID: Initial Trial Results After 4 Years

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Science  20 Oct 1995:
Vol. 270, Issue 5235, pp. 475-480
DOI: 10.1126/science.270.5235.475

Article Information

vol. 270 no. 5235 475-480

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Author Information

  1. R. Michael Blaese(1),
  2. Kenneth W. Culver,
  3. A. Dusty Miller,
  4. Charles S. Carter,
  5. Thomas Fleisher,
  6. Mario Clerici(2),
  7. Gene Shearer,
  8. Lauren Chang,
  9. Yawen Chiang,
  10. Paul Tolstoshev,
  11. Jay J. Greenblatt,
  12. Steven A. Rosenberg,
  13. Harvey Klein,
  14. Melvin Berger,
  15. Craig A. Mullen(3),
  16. W. Jay Ramsey,
  17. Linda Muul,
  18. Richard A. Morgan,
  19. W. French Anderson(4)
  1. R. M. Blaese, C. A. Mullen, W. J. Ramsey, National Center for Human Genome Research, National Institutes of Health (NIH), Building 49, Room 2A03, Bethesda, MD 20892, USA, and National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA.
  2. K. W. Culver, M. Clerici, G. Shearer, J. J. Greenblatt, S. A. Rosenberg, NCI, NIH, Bethesda, MD 20892, USA.
  3. A. D. Miller, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
  4. C. S. Carter, T. Fleisher, H. Klein, Clinical Center, NIH, Bethesda, MD 20892, USA.
  5. L. Chang and W. F. Anderson, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD 20892, USA.
  6. Y. Chiang and P. Tolstoshev, Genetic Therapy, Gaithersburg, MD 20878, USA.
  7. M. Berger, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  8. L. Muul, National Center for Human Genome Research, NIH, Bethesda, MD 20892, USA.
  9. R. A. Morgan, National Center for Human Genome Research, NIH, Bethesda, MD 20892, USA, and NHLBI, NIH, Bethesda, MD 20892, USA.
  1. (1) To whom correspondence should be addressed at the National Center for Human Genome Research. E-mail:mblaese{at}nchgr.nih.gov
  2. (2) Present address: Cattedra Di Immunogia, Universita Milano, Milan 20133, Italy.
  3. (3) Present address: Division of Pediatrics, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
  4. (4) Present address: Norris Cancer Center, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.

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