Molecular Mimicry in Protein Synthesis?

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Science  01 Dec 1995:
Vol. 270, Issue 5241, pp. 1453
DOI: 10.1126/science.270.5241.1453


A Research Article in this issue of Science by P. Nissen et al. (p. 1464) reports the crystal structure of elongation factor Tu (EF-Tu) complexed with tRNA and GTP. In his Perspective, P. Moore discusses the similarity between this new structure and the GDP-bound form of elongation factor G. Three domains at the carboxyl-terminal end of EF-G, which have no homologs in EF-Tu, together resemble tRNA and are positioned like the tRNA bound to EF-Tu.