ENHANCED PERSPECTIVE: Small RNA Chaperones for Ribosome Biogenesis

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Science  08 Dec 1995:
Vol. 270, Issue 5242, pp. 1626
DOI: 10.1126/science.270.5242.1626


The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536-0812, USA. A set of small nuclear RNAs of 50 to 200 nucleotides resides in the nucleolus of the cell, the region of the nucleus in which ribosomes are made. J. A. Steitz and K. T. Tycowski discuss what is known about how these RNAs participate in the conversion of the long precursor RNAs to the mature 18S, 5.8S, and 28S rRNAs of the ribosome.

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