A New Guide to the Human Genome

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Science  22 Dec 1995:
Vol. 270, Issue 5244, pp. 1919-1920
DOI: 10.1126/science.270.5244.1919


Researchers looking to accomplish the ultimate goal of the Human Genome Project—the complete sequencing of all 3 billion bases in the genome—now have a major new tool to help them. In an article also appearing in this issue (p. 1945), Eric Lander's team at the Whitehead Institute for Biomedical Research describes a detailed new physical map of the human genome. Not only is its coverage more complete than that of previous maps, but the landmarks used, which are called sequence-tagged sites, make it more versatile and easier to use. While not yet as detailed as sequencers want, it opens the door to genomewide sequencing.