Genetic Clues to Alzheimer's Disease

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Science  12 Jan 1996:
Vol. 271, Issue 5246, pp. 159
DOI: 10.1126/science.271.5246.159


All cases of familial Alzheimer's disease are caused by mutations in either the gene for beta-amyloid precursor protein or the protein S182/STM. The normal functions of these transmembrane proteins are unknown, and it is unclear how they relate to one another. N. N. Dewji and S. J. Singer propose that these two proteins interact in a way analogous to the Sevenless and Bride of Sevenless proteins in the developing Drosophila eye and the lin-12 and sel-12 proteins in the developing vulva of Caenorhabditis elegans. He suggests that excess deposition of amyloid, a hallmark and likely cause of Alzheimer's disease, would be a result of the abnormal processing of the protein-protein complex.

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