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IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

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Science  02 Feb 1996:
Vol. 271, Issue 5249, pp. 665-670
DOI: 10.1126/science.271.5249.665

Article Information

vol. 271 no. 5249 665-670

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Author Information

  1. Gökhan S. Hotamisligil(1),
  2. Pascal Peraldi,
  3. Adriane Budavari,
  4. Ramsey Ellis,
  5. Morris F. White,
  6. Bruce M. Spiegelman(2)
  1. G. S. Hotamisligil, P. Peraldi, A. Budavari, R. Ellis, B. M. Spiegelman, Department of Cellular and Molecular Biology, Dana-Farber Cancer Institute, and Department of Cell Biology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
  2. M. F. White, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.
  1. (1) Present address: Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
  2. (2) To whom correspondence should be addressed. E-mail: bruce_spiegelman{at}dfci.harvard.edu

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