Induction of Protective CTL Responses in Newborn Mice by a Murine Retrovirus

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Science  22 Mar 1996:
Vol. 271, Issue 5256, pp. 1726-1728
DOI: 10.1126/science.271.5256.1726


The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.

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