Research Article

Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled

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Science  29 Mar 1996:
Vol. 271, Issue 5257, pp. 1826-1832
DOI: 10.1126/science.271.5257.1826


In Drosophila, the Wingless and Notch signaling pathways function in many of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Wingless signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.

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