Population Dynamics of Immune Responses to Persistent Viruses

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Science  05 Apr 1996:
Vol. 272, Issue 5258, pp. 74-79
DOI: 10.1126/science.272.5258.74


Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic T cell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).

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