12 April 1996
Vol 272, Issue 5259

About The Cover

Confocal microscope image of a section from an adult rat brain injected 4 weeks earlier with a human immunodeficiency virus-based vector expressing -galactosidase (-gal). The section was stained by immunofluorescence with antibodies to -gal (green), the neuronal-specific marker NeuN (red), and the astrocytic protein GFAP (blue). A -gal-expressing neuron (doubly stained, yellow) shows that the vector can transfer genes into nondividing cells, a desirable trait in gene therapy. Image width: ~240 micrometers. See 263 and the related News story on 195. [Image: U. Blömer and F. H. Gage]