Independent Modes of Natural Killing Distinguished in Mice Lacking Lag3

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Science  19 Apr 1996:
Vol. 272, Issue 5260, pp. 405-408
DOI: 10.1126/science.272.5260.405


The LAG3 protein has several features in common with CD4, suggesting that it may be important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment. Killing of certain tumor targets by natural killer cells from these mice was inhibited or even abolished, whereas lysis of cells displaying major histocompatibility complex class I disparities remained intact. It appears that LAG3 is a receptor or coreceptor that defines different modes of natural killing.

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