Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

Hidehiro Ishii; Michael R. Jirousek; Daisuke Koya; Chikako Takagi; Pu Xia; Allen Clermont; Sven-Erik Bursell; Timothy S. Kern; Lawrence M. Ballas; William F. Heath; Lawrence E. Stramm; Edward P. Feener; George L. King

doi:10.1126/science.272.5262.728

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Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

Hidehiro Ishii,
Michael R. Jirousek,
Daisuke Koya,
Chikako Takagi,
Pu Xia,
Allen Clermont,
Sven-Erik Bursell,
Timothy S. Kern,
Lawrence M. Ballas,
William F. Heath,
Lawrence E. Stramm,
Edward P. Feener,
George L. King *

H. Ishii, D. Koya, C. Takagi, P. Xia, A. Clermont, S.-E. Bursell, E. P. Feener, G. L. King, Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.
M. R. Jirousek, W. F. Heath, L. E. Stramm, Lilly Laboratories, Indianapolis, IN 46285, USA.
T. S. Kern, Department of Ophthalmology, University of Wisconsin, Madison, WI 53706, USA.
L. M. Ballas, Sphinx Pharmaceutical, Durham, NC 27707, USA.

↵* To whom correspondence should be addressed.

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Science 03 May 1996:
Vol. 272, Issue 5262, pp. 728-731
DOI: 10.1126/science.272.5262.728

Hidehiro Ishii

H. Ishii, D. Koya, C. Takagi, P. Xia, A. Clermont, S.-E. Bursell, E. P. Feener, G. L. King, Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.

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Michael R. Jirousek

M. R. Jirousek, W. F. Heath, L. E. Stramm, Lilly Laboratories, Indianapolis, IN 46285, USA.

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Daisuke Koya

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Chikako Takagi

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Pu Xia

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Allen Clermont

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Sven-Erik Bursell

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Timothy S. Kern

T. S. Kern, Department of Ophthalmology, University of Wisconsin, Madison, WI 53706, USA.

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Lawrence M. Ballas

L. M. Ballas, Sphinx Pharmaceutical, Durham, NC 27707, USA.

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William F. Heath

M. R. Jirousek, W. F. Heath, L. E. Stramm, Lilly Laboratories, Indianapolis, IN 46285, USA.

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Lawrence E. Stramm

M. R. Jirousek, W. F. Heath, L. E. Stramm, Lilly Laboratories, Indianapolis, IN 46285, USA.

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Edward P. Feener

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George L. King

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Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

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