Polyclonal Origin of Colonic Adenomas in an XO/XY Patient with FAP

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Science  24 May 1996:
Vol. 272, Issue 5265, pp. 1187-1190
DOI: 10.1126/science.272.5265.1187


It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.

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