The "Bio" in Biochemistry--Protein Folding Inside and Outside the Cell

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Science  07 Jun 1996:
Vol. 272, Issue 5267, pp. 1448
DOI: 10.1126/science.272.5267.1448


After proteins are made, they must be folded into their final structure. In a report in this week's issue of Science, Frydman and Hartl, on page 1497, compare how molecular chaperones (proteins that assist folding) affect folding of proteins as they are synthesized from ribosomes and proteins that have been artificially denatured. In his Perspective, Ellis discusses why the differences that are found tell us something about how chaperones really work in the cell.

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