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A Second Coreceptor for HIV in Early Stages of Infection

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Science  21 Jun 1996:
Vol. 272, Issue 5269, pp. 1740
DOI: 10.1126/science.272.5269.1740


Two papers published in this week's issue of Nature and a third that will appear in the 28 June issue of Science (with independent results from at least one other team reportedly about to be published) report the identification of an essential “coreceptor” for the HIV strains involved in the critical early stages of infection. All have fingered a cell membrane-bound protein called CC-CKR-5 as the elusive partner of HIV's primary receptor, CD4, in allowing these strains to enter their target cells. Last month, another coreceptor, called “fusin,” was reported in Science (10 May, p. 809). The discovery of these two coreceptors--and perhaps others yet to be identified--suggests that HIV may use different molecules to enter the cell at different stages of the disease.