Receptor Tails Unlock Developmental Checkpoints for B Lymphocytes

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Science  21 Jun 1996:
Vol. 272, Issue 5269, pp. 1752-1754
DOI: 10.1126/science.272.5269.1752


Two reports, one previously published in Science (Gong and Nussenzweig, 19 April, p. 411) and one in this week's issue (Torres et al., p. 1804), report the surprising phenotypes of genetically engineered (knockout) mice missing the Ig-alpha and Ig-beta accessory proteins of the B cell antigen receptor. DeFranco and Roth discuss in their Perspective how the characteristics of these mice reveal two new checkpoints in the developmental pathway of the B cell.