Markers on Distal Chromosome 2q Linked to Insulin-Dependent Diabetes Mellitus

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Science  21 Jun 1996:
Vol. 272, Issue 5269, pp. 1811-1813
DOI: 10.1126/science.272.5269.1811


Insulin-dependent diabetes mellitus (IDDM) is a multigenic autoimmune disease. An IDDM susceptibility gene was mapped to chromosome 2q34. This gene may act early in diabetogenesis, because “preclinical” individuals also showed linkage. Human leukocyte antigen (HLA)-disparate, but not HLA-identical, sibs showed linkage, which was even stronger in families with affected females. The genes encoding insulin-like growth factor-binding proteins 2 and 5 were mapped to a 4-megabase pair interval near this locus. These results indicate the existence of a gene that acts at an early stage in IDDM development, screening for which may identify a specific subset of at-risk individuals.

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