T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

See allHide authors and affiliations

Science  05 Jul 1996:
Vol. 273, Issue 5271, pp. 104-106
DOI: 10.1126/science.273.5271.104


The requirements for T cell activation have been reported to vary widely depending on the state of the T cell, the type of antigen-presenting cell, and the nature of the T cell receptor (TCR) ligand. A unitary requirement for T cell responses was revealed by measurement of the number of triggered TCRs. Irrespective of the nature of the triggering ligand, T cells “counted” the number of triggered TCRs and responded when a threshold of ∼8000 TCRs was reached. The capacity to reach the activation threshold was severely compromised by a reduction in the number of TCRs. Costimulatory signals lowered the activation threshold to ∼1500 TCRs, thus making T cells more sensitive to antigenic stimulation.

Stay Connected to Science