Evidence for Physical and Functional Association Between EMB-5 and LIN-12 in Caenorhabditis elegans

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Science  05 Jul 1996:
Vol. 273, Issue 5271, pp. 112-115
DOI: 10.1126/science.273.5271.112


The Caenorhabditis elegans LIN-12 and GLP-1 proteins are members of the LIN-12/Notch family of receptors for intercellular signals that specify cell fate. Evidence presented here suggests that the intracellular domains of LIN-12 and GLP-1 interact with the C. elegans EMB-5 protein and that the emb-5 gene functions in the same pathway as the lin-12 and glp-1 genes. EMB-5 is similar in sequence to a yeast protein that controls chromatin structure. Hence, a direct consequence of LIN-12 or GLP-1 activation may be an alteration of chromatin structure that produces changes in transcriptional activity.