Polar Overdominance at the Ovine callipyge Locus

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Science  12 Jul 1996:
Vol. 273, Issue 5272, pp. 236-238
DOI: 10.1126/science.273.5272.236


An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.

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