26 July 1996
Vol 273, Issue 5274

About The Cover

A peptide dimer (orange) that mimics erythropoietin hormone (EPO) binds two equivalent EPO receptor extracellular domains (blue) and produces the signal necessary to stimulate production of red blood cells. The crystal structure of the complex identifies one functional mode of receptor dimerization. The peptide interaction with a functional epitope on each receptor is a basis for the design of small-molecule EPO mimetics. See 464 and the related Research Article (458) and Perspective (449). [Image: M. Pique, O. Livnah, and I. A. Wilson]